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vcfanno for Mac

Annotate a VCF with other VCFs/BEDs/tabixed files

In short: vcfanno is a macOS command-line tool. Install it with brew install vcfanno. It is distributed under the MIT licence.

What is vcfanno?

vcfanno is a macOS command-line tool: Annotate a VCF with other VCFs/BEDs/tabixed files.

It is distributed as a Homebrew formula, which builds or unpacks binaries onto your PATH. It is distributed under the MIT licence.

How to install vcfanno

  1. Open Terminal (press ⌘ + Space and type “Terminal”).
  2. If Homebrew is not installed, run the install command below first.
  3. Run brew install vcfanno.

Install Homebrew first if needed:

Prefer a graphical installer? Download it from the official website . This site never hosts or mirrors binaries: the Homebrew command always pulls from the vendor's own release.

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Frequently asked questions

How do I install vcfanno on a Mac?

Run brew install vcfanno in Terminal. This requires Homebrew; install it first with the command below if needed.

Is vcfanno open source?

Yes — Homebrew distributes it under the MIT licence.

Does vcfanno run on Apple silicon?

Homebrew provides this formula for macOS. If upstream does not publish an Apple silicon build, Rosetta 2 can run the Intel binary.

How popular is vcfanno?

Homebrew does not publish a 30-day install count for this package, which usually means installs happen outside its opt-in analytics.

What version of vcfanno is current?

The latest packaged version is 0.3.9.

Data comes from the public Homebrew API, last updated 2026-10-27. Install counts only include Homebrew installs and are not total users.

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